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Association of the Geriatric 8 with treatment intensity and prognosis in older patients with diffuse large B‐cell lymphoma
Author(s) -
Lee Shin,
Fujita Kei,
Morishita Tetsuji,
Oiwa Kana,
Tsukasaki Hikaru,
Negoro Eiju,
Hara Takeshi,
Tsurumi Hisashi,
Ueda Takanori,
Yamauchi Takahiro
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17554
Subject(s) - diffuse large b cell lymphoma , hazard ratio , medicine , confidence interval , proportional hazards model , oncology , lymphoma
Summary Because of the heterogeneity among older patients with diffuse large B‐cell lymphoma (DLBCL), the establishment of an easy‐to‐use geriatric assessment tool is an unmet need. We verified the impact of the Geriatric 8 (G8) on treatment stratification and overall survival (OS). We conducted a retrospective, multicentre analysis of older patients (≥65 years) with DLBCL. The primary endpoint was OS. The total average relative dose intensity (tARDI) was defined as the average delivered dose intensity divided by the planned dose intensity through all cycles. A total of 451 patients were diagnosed with DLBCL from 2007 to 2017, and 388 patients received standard regimens. A multivariate Cox model confirmed that the G8 was a significant predictor of OS (hazard ratio 0·88, 95% confidence interval 0·828–0·935). A Cox model with restricted cubic spline showed a linear association between the G8 and the mortality risk. The G8 had a significant impact on OS in elderly patients with DLBCL. The upper limit of tARDI for standard regimens to improve OS might be appropriate at ≥80% for patients with high G8 scores and 60% for patients with low G8 scores. However, the standard regimens should be given to all patients regardless of the G8 score to improve OS.