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Incidence, characteristics and clinical profile of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection in patients with pre‐existing primary immune thrombocytopenia (ITP) in Spain
Author(s) -
MingotCastellano María E.,
AlcaldeMellado Patricia,
PascualIzquierdo Cristina,
Perez Rus Gloria,
Calo Pérez Aida,
Martinez María P.,
LópezJaime Francisco J.,
Abalo Perez Lorena,
GonzalezPorras José R.,
López Fernández Fernanda,
Caparrós Miranda Isabel S.,
GonzálezLópez Tomás J.,
Moreno Beltrán María E.,
Rubio Escuin Rebeca,
Jimenez Bárcenas Reyes
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17506
Subject(s) - medicine , incidence (geometry) , immunosuppression , immune thrombocytopenia , coronavirus , middle east respiratory syndrome coronavirus , immunology , covid-19 , immune system , respiratory system , disease , platelet , infectious disease (medical specialty) , physics , optics
Summary Infections are one of the well‐known precipitating factors for relapses in patients with immune thrombocytopenia (ITP). Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection can sometimes lead to or be associated with thrombocytopenia due to an increase in peripheral platelet destruction from inflammatory hyperactivation. Currently, we do not know if SARS‐CoV‐2 infection modifies the natural evolution of chronic or persistent ITP or if previous immunosuppression of patients with ITP influences the incidence and severity of coronavirus disease 2019 (COVID‐19) in this group. The present study was an observational, multicentre, national series of 32 adult patients with pre‐existing ITP and subsequent SARS‐CoV‐2 infection, collected by the Spanish ITP Group [Grupo Español de Trombocitopenia Inmune (GEPTI)].