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Insight into del17p low‐frequency subclones in chronic lymphocytic leukaemia (CLL): data from the Australasian Leukaemia and Lymphoma Group (ALLG)/CLL Australian Research Consortium (CLLARC) CLL5 trial
Author(s) -
Do Cuc,
Best O. Giles,
Thurgood Lauren,
Hotinski Anya,
Apostolou Sinoula,
Mulligan Stephen P.,
Lower Karen,
Kuss Bryone
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17394
Subject(s) - medicine , lymphoma , overall survival , oncology , gastroenterology
Summary The clinical significance of low‐frequency deletions of 17p13 [tumour protein p53 ( TP53 )] in patients with chronic lymphocytic leukaemia (CLL) is currently unclear. Low‐frequency del17p clones (<25%) were identified in 15/95 patients in the Australasian Leukaemia and Lymphoma Group (ALLG)/CLL Australian Research Consortium (CLLARC) CLL5 trial. Patients with low del17p, without tumour protein p53 ( TP53 ) mutation, had significantly longer progression‐free survival and overall survival durations than patients with high del17p clones. In 11/15 cases with low‐frequency del17p, subclones solely with del17p or del13q were also noted. These data suggest that low‐frequency del17p does not necessarily confer a poor outcome in CLL and challenges the notion of del13q as a founding event in CLL.