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Paediatric chronic myeloid leukaemia presenting in de novo or secondary blast phase ‐ a comparison of clinical and genetic characteristics
Author(s) -
Sembill Stephanie,
Göhring Gudrun,
Schirmer Elke,
Lutterloh Friederike,
Suttorp Meinolf,
Metzler Markus,
Karow Axel
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17378
Subject(s) - chronic myeloid leukaemia , medicine , cohort , pediatrics , clinical trial , myeloid , karyotype , oncology , chromosome , genetics , biology , gene
Summary Additional data on blast phase (BP) chronic myeloid leukaemia (CML) in children and adolescents is essential for improving diagnostic and therapeutic approaches of this rare but serious condition. Here, we describe distinct clinical and genetic characteristics of 18 paediatric patients with de novo ( n = 10) and secondary ( n = 8) BP CML enrolled in the CML‐PAED‐II trial and registry. Our findings suggest that paediatric patients exhibit a diverse cytogenetic profile compared to adults with BP CML. In addition, patients with de novo BP CML in this cohort presented at a younger age, whereas patients with secondary BP CML more often harboured complex karyotypes.