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Factor VIII levels and bleeding according to factor 8 ( F8 ) mutation in pregnant carriers of haemophilia A: a multicentre retrospective cohort study
Author(s) -
Collins Annie E. I.,
Curry Nicola,
RazaBurton Sayma,
Bignell Patricia,
Davies Claire,
Joffe Michael,
Shapiro Susan,
Desborough Michael J. R.
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17254
Subject(s) - medicine , haemophilia a , haemophilia , retrospective cohort study , pregnancy , coagulopathy , hemarthrosis , cohort , gastroenterology , risk factor , haemophilia b , obstetrics , surgery , biology , genetics
Summary This retrospective cohort study investigated the association between factor 8 ( F8 ) genotype severity and factor VIII (FVIII) levels during pregnancy for 52 women (64 pregnancies) who were heterozygous carriers of mild, moderate or severe haemophilia A. There were no significant differences in FVIII levels for carriers of mild, moderate or severe haemophilia A at baseline [mean (SD) level: mild, 0·78 (0·22); moderate, 0·83 (0·33); severe, 0·70 (0·25) iu/ml; P = 0·81] or in the third trimester [mean (SD) level: mild, 1·42 (0·28); moderate, 1·47 (0·41); severe, 1·37 (0·49) iu/ml; P = 0·80). Post‐partum haemorrhage rates were higher for carriers of severe haemophilia A (13/24; 54·2%) compared to carriers of mild haemophilia A (four of 14; 28·6%).