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Genome‐wide DNA methylation analysis along the progression of gastric marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT) type
Author(s) -
Dugge Rucha,
Wagener Rabea,
Mӧller Peter,
Barth Thomas F. E.
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17193
Subject(s) - dna methylation , biology , methylation , marginal zone , lymphoma , mucosa associated lymphoid tissue , helicobacter pylori , lymphatic system , gastric mucosa , pathology , malt lymphoma , cancer research , dna , stomach , b cell , gene , genetics , immunology , medicine , gene expression , antibody , biochemistry
Summary Extra‐nodal marginal zone B‐cell lymphoma (MZBL) of mucosa‐associated lymphoid tissue is an indolent lymphoma mostly affecting the gastrointestinal tract. The lymphoma initially has small‐cell morphology (SC‐MZBL) and often arises in the background of Helicobacter pylori ‐induced gastritis. In some cases, a clonal malignant progression to large‐cell morphology (LC‐MZBL) is observed. Here, we studied the DNA methylation profile of 30 gastric MZBLs along their progression. Genome‐wide DNA methylation profiling, identified 7698 significantly differentially methylated loci during gastric MZBL progression (σ/σ max ≥0·4, q ≤ 0·001). LC‐MZBL showed hypermethylation in comparison to SC‐MZBL with an enrichment of regions involved in transcriptional regulation. In conclusion, our present data show that the morphological distinction between SC‐ and LC‐MZBL is reflected by characteristic DNA methylation profiles.