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Baseline correlations and prognostic impact of serum monoclonal proteins in follicular lymphoma
Author(s) -
Mozas Pablo,
Rivero Andrea,
RivasDelgado Alfredo,
Fabregat Aleix,
Piñeyroa Juan A.,
Correa Juan G.,
Nadeu Ferran,
Oliver Aina,
Bataller Alex,
Giné Eva,
Delgado Julio,
Villamor Neus,
Cibeira Maria T.,
Fernández de Larrea Carlos,
Rosiñol Laura,
Campo Elías,
Aróstegui Juan I.,
Bladé Joan,
Magnano Laura,
LópezGuillermo Armando
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17138
Subject(s) - medicine , hazard ratio , confidence interval , follicular lymphoma , lymphoma , gastroenterology
Summary The presence of a serum monoclonal component has been associated with poor outcomes in some lymphomas. However, data in follicular lymphoma (FL) are scarce. We studied 311 FL patients diagnosed at a single institution, for whom information on serum immunofixation electrophoresis (sIFE) at diagnosis was available. Baseline characteristics and outcomes were compared between patients with a positive (+sIFE) and a negative sIFE (−sIFE). sIFE was positive in 82 patients (26%). Baseline features were comparable between both groups, except for an older age and higher proportion of elevated β 2 ‐microglobulin levels in the +sIFE group. With a median follow‐up of 4.6 years, a +sIFE was associated with a higher risk of early relapse (POD24, 27% vs. 15%, P = 0·02), shorter progression‐free survival (PFS; 42% vs. 52% at 5 years, P = 0·008), and shorter overall survival (OS; 59% vs. 77% at 10 years, P = 0·046). In patients >60 years, a +sIFE was an independent predictor of OS [hazard ratio (HR) = 2·4, 95% confidence interval (CI): 1·2–5·0; P = 0·02]. Approximately one quarter of patients with FL has a +sIFE at diagnosis, which is a predictor of poor outcome. These findings encourage further investigation of its relationship with B‐cell biology and the tumour microenvironment.