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Altered immune response to the annual influenza A vaccine in patients with myeloproliferative neoplasms
Author(s) -
Alimam Samah,
Ann Timms Jessica,
Harrison Claire N.,
Dillon Richard,
Mare Tracey,
DeLavallade Hugues,
Radia Deepti,
Woodley Claire,
Francis Yvonne,
Sanchez Katy,
Kordasti Shahram,
McLornan Donal P.
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17096
Subject(s) - immune system , vaccination , medicine , immunology , immunophenotyping , influenza vaccine , immune dysfunction , antigen
Summary The seasonal influenza A vaccine is recommended for patients with myeloproliferative neoplasms (MPNs). We hypothesised that immune deregulation associated with MPNs may affect the immune response gained following vaccinations when compared to healthy controls. Using deep immunophenotyping with high‐dimensional single‐cell analysis and mass cytometry we could demonstrate an altered immune response in MPN patients following vaccination. We found that prior to vaccination, MPN patients had reduced numbers of naive CD4 T cells. Furthermore, at 3‐weeks and 3‐months post‐vaccination there was evidence of both delayed and impaired B‐ and T‐memory cells responses. Thus, although, the immune systems of MPN patients can 'recognise' the Influenza A vaccine, the response appears inferior compared to healthy controls.