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Diagnostic performance of 18 F‐FDG‐PET/CT compared to standard skeletal survey for detecting bone destruction in smouldering multiple myeloma: time to move forward
Author(s) -
Hill Elizabeth,
Mena Esther,
Morrison Candis,
Dew Alexander,
Choyke Peter,
Lindenberg Liza,
Kazandjian Dickran
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17088
Subject(s) - multiple myeloma , nuclear medicine , medicine , positron emission tomography , skeletal survey , radiology
Summary Skeletal survey (SS) continues to be used in the community to detect bone disease in patients with multiple myeloma (MM). While the false‐negative rate is high, the specificity of SS is less well characterised. Here, we compare the diagnostic accuracy of SS compared to 18 F‐FDG‐PET/CT (positron emission tomography/computed tomography) in 79 patients referred to our tertiary centre with a diagnosis of smouldering MM. SS had a specificity of 83·1% (95% confidence interval: 72·0–90·5%). This study reinforces the importance of using more specific imaging techniques to avoid inaccurate diagnosis that could lead to the risks associated with unnecessary therapy in patients with smouldering MM.