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Early intracranial haemorrhages in acute promyelocytic leukaemia: analysis of neuroradiological and clinico‐biological parameters
Author(s) -
Gurnari Carmelo,
Breccia Massimo,
Di Giuliano Francesca,
Scalzulli Emilia,
Divona Mariadomenica,
Piciocchi Alfonso,
Cicconi Laura,
De Bellis Eleonora,
Venditti Adriano,
Del Principe Maria Ilaria,
Arcese William,
LoCoco Francesco,
Garaci Francesco,
Voso Maria Teresa
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17018
Subject(s) - medicine , hydrocephalus , complication , fibrinogen , pediatrics , surgery , radiology
Summary Acute promyelocytic leukaemia (APL) represents a modern success of precision medicine. However, fatalities occurring within the first 30 days of induction treatment, in particular intracranial haemorrhage (ICH), remain the main causes of death. We studied the clinico‐biological characteristics of 13 patients with APL who experienced ICH. Compared to 85 patients without this complication, patients with ICH were older and more frequently had high‐risk APL. Moreover, positivity for the ‘swirl’ sign at neuroradiological imaging and hydrocephalus were predictors of a fatal outcome, together with lower fibrinogen, prolonged international normalized ratio (INR) and higher lactate dehydrogenase levels.