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Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia
Author(s) -
Corbingi Andrea,
Innocenti Idanna,
Tomasso Annamaria,
Pasquale Raffaella,
Visentin Andrea,
Varettoni Marzia,
Flospergher Elena,
Autore Francesco,
Morelli Francesca,
Trentin Livio,
Reda Gianluigi,
Efremov Dimitar G.,
Laurenti Luca
Publication year - 2020
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16975
Subject(s) - chronic lymphocytic leukemia , medicine , monoclonal gammopathy of undetermined significance , gammopathy , immunoglobulin m , monoclonal gammopathy , trisomy , antibody , immunology , waldenstrom macroglobulinemia , multiple myeloma , monoclonal , immunoglobulin g , monoclonal antibody , leukemia , biology , lymphoma , genetics
Summary The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo‐γ) and normal Ig levels (γ‐normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/ TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment‐free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.