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C1 esterase inhibitor and the contact system in COVID‐19
Author(s) -
Thomson Timothy M.,
ToscanoGuerra Emily,
Casis Ernesto,
Paciucci Rosanna
Publication year - 2020
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16938
Subject(s) - covid-19 , virology , contact system , coronavirus infections , medicine , outbreak , infectious disease (medical specialty) , disease , mechanical engineering , engineering
Summary Coronavirus disease 2019 (COVID‐19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life‐threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus‐2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen‐specific mechanism that may help explain significant systemic abnormalities in patients with COVID‐19.