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Clonal relationship in multisited mucosa‐associated lymphoid tissue lymphomas: a single‐centre experience
Author(s) -
Condom Maria,
Climent Fina,
Fernández Davinia,
Colomer Dolors,
LopezGuerra Mónica,
Varela Mar,
Carro Itziar,
Maluquer Clara,
Mercadal Santiago,
Oliveira Ana Carla,
Pané Maria,
MatiasGuiu Xavier,
GonzálezBarca Eva,
Sureda Anna,
DomingoDomenech Eva
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16717
Subject(s) - malt lymphoma , mucosa associated lymphoid tissue , clone (java method) , lymphoma , somatic evolution in cancer , lymphatic system , gastrointestinal tract , immunoglobulin heavy chain , biology , pathology , disease , polymerase chain reaction , immunology , antibody , medicine , cancer , gene , genetics
Summary Clonal heterogeneity in multisited or recurrent lymphoid neoplasms is a phenomenon that has been increasingly studied in recent years. However, in mucosa‐associated lymphoid tissue (MALT) lymphomas it remains largely unexplored. Patients diagnosed at our institution with multisited MALT lymphoma, from January 2009 to October 2018, were studied. Molecular studies were performed for the detection of clonally rearranged immunoglobulin by polymerase chain reaction.In all, 91 patients were included. Of those, 28 had a multisited disease and in 16 clonality studies were done. In eight cases, multifocal involvement was synchronous and in eight metachronous. Patients with non‐gastric gastrointestinal tract involvement tended to disseminate within the same tract, without observing other specific dissemination patterns. Four cases (25%) had clonal heterogeneity at the different organs involved. All patients with late relapses (two patients) had different clones. The majority of patients with multisited MALT lymphomas presented with the same clone in the different involved organs, identifying a different clone in those with late relapses. These patients could represent de novo neoplasms, rather than a relapse. This could mean that some individuals might have a genetic predisposition to develop this type of lymphoma and it could also have clinical implications regarding therapeutic decisions.