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TARGET: a survey of real‐world management of chronic myeloid leukaemia across 33 countries
Author(s) -
Turkina Anna,
Wang Jianxiang,
Mathews Vikram,
Saydam Guray,
Jung Chul Won,
Al Hashmi Hani Hassan,
Yassin Mohamed,
Le Clanche Solenn,
Miljkovic Darko,
Slader Cassandra,
Hughes Timothy P.
Publication year - 2020
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16599
Subject(s) - medicine , government (linguistics) , work (physics) , family medicine , intensive care medicine , philosophy , linguistics , mechanical engineering , engineering
Summary Despite the availability of guidelines for the management of chronic myeloid leukaemia (CML), various issues may prevent their successful implementation. The TARGET survey examined real‐world management of CML patients compared with international recommendations. This online survey was completed in 2017. Results were discussed by a Steering Committee (SC) of eight international haematologists, challenges were identified and practical solutions developed. Of the 1008 haematologists invited (33 countries), 614 completed the survey. Gaps regarding treatment efficacy and molecular monitoring were identified. Half of the physicians did not perform three‐monthly testing of during the initial 12 months of treatment, citing cost as the major barrier, although they know it should be done. Treatment‐free remission was not considered a primary treatment goal or as a priority factor influencing treatment decisions. European Leukemia Net guidelines interpretation was generally acceptable, but awareness regarding management of persistent adverse events was poor. Practical solutions proposed by the SC were mostly focused on enhancing physician education and awareness, or encouraging hospitals to work with the government, in order to improve the quality of BCR‐ABL testing. Gaps in current CML management were identified compared with international recommendations, which the proposed practical solutions would help to address.