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The derived neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in patients with angioimmunoblastic T‐cell lymphoma
Author(s) -
Hong Huangming,
Fang Xiaojie,
Huang He,
Wang Zhao,
Lin Tongyu,
Yao Herui
Publication year - 2020
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16447
Subject(s) - angioimmunoblastic t cell lymphoma , medicine , neutrophil to lymphocyte ratio , multivariate analysis , univariate analysis , lymphoma , lymphocyte , gastroenterology , univariate , trimethylgallium , oncology , immunology , multivariate statistics , t cell , chemistry , immune system , statistics , mathematics , metalorganic vapour phase epitaxy , epitaxy , organic chemistry , layer (electronics)
Summary To determine whether inflammatory markers, derived neutrophil‐to‐lymphocyte ratio (dNLR), haemoglobin/platelet ratio (HPR) or platelet/lymphocyte ratio (PLR) are predictive for prognosis in angioimmunoblastic T‐cell lymphoma (AITL), we derived dNLR, HPR and PLR values for 110 AITL patients and appropriate cut‐off point values to define overall survival (OS) and progression‐free survival (PFS). dNLR ≥ 2·2, HPR ≥ 0·4 or PLR < 100 were significant factors for shorter OS and PFS. On univariate analysis, these three parameters were significantly associated with worse OS and PFS. On multivariate analysis, only dNLR remained a significant, independent prognostic factor for both OS and PFS.