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Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation
Author(s) -
Awada Hassan,
Mahfouz Reda Z.,
Durrani Jibran,
Kishtagari Ashwin,
Jagadeesh Deepa,
Lichtin Alan E.,
Hill Brian T.,
Hamilton Betty K.,
Carraway Hetty E.,
Nazha Aziz,
Majhail Navneet S.,
Sobecks Ronald,
Visconte Valeria,
Kalaycio Matt,
Sekeres Mikkael A.,
Maciejewski Jaroslaw P.
Publication year - 2020
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16336
Subject(s) - transplantation , immunology , stem cell , haematopoiesis , disease , immune system , lymphoproliferative disorders , medicine , biology , pathology , lymphoma , genetics
Summary T‐cell large granular lymphocytic leukaemia (T‐LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T‐LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, we studied the clinical characterization of these cases and compared them to de novo T‐LGLL. This experience represented a clear picture of the intricate nature of the disease manifestation and the complexities of several immune mechanisms triggering the clonal expansion.