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Intestinal pathophysiological and microbial changes in sickle cell disease: Potential targets for therapeutic intervention
Author(s) -
Dutta Dibyendu,
Aujla Amandeep,
Knoll Bettina M.,
Lim Seah H.
Publication year - 2020
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16273
Subject(s) - pathophysiology , pathogenesis , disease , medicine , immunology , inflammation , therapeutic effect , basal (medicine) , bioinformatics , biology , insulin
Summary There is a large therapeutic gap in the treatment of sickle cell disease (SCD). Recent studies demonstrated the presence of pathophysiological and microbial changes in the intestine of patients with SCD. The intestinal microbes have also been found to regulate neutrophil ageing and possible basal activation of circulating neutrophils. Both aged and activated neutrophils are pivotal for the pathogenesis of vaso‐occlusive crisis in SCD. In this paper, we will provide an overview of the intestinal pathophysiological and microbial changes in SCD. Based on these changes, we will propose therapeutic approaches that could be investigated for treating SCD.