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Outcomes of acute lymphoblastic leukaemia in adolescent and young adult Korean patients
Author(s) -
Kim Young Ae,
Ju Hee Young,
Park Hyeon Jin,
Lee Na Young,
Lee Hyun Jeong,
Lee Hyewon,
Ghang Haryeom
Publication year - 2020
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16242
Subject(s) - medicine , young adult , asparaginase , chemotherapy , radiation therapy , lymphoblastic leukemia , pediatrics , oncology , leukemia
This study used Korean national data to investigate the relationship between treatment patterns and outcomes in Korean adolescent and young‐adult (AYA) acute lymphoblastic leukaemia (ALL) patients. Chemotherapy incorporating L‐asparaginase was considered paediatric‐inspired (PI), as opposed to adult protocols. In total, 65·3% of patients received PI therapy. Five‐year overall survival (OS) of PI‐treated patients outperformed adult protocols (63·1% vs. 40·4%; P < 0·0001); this trend was maintained within various age subgroups. Younger age, L‐asparaginase therapy, and radiotherapy corresponded with superior OS by multivariable analysis. OS tends to improve with PI protocols that include L‐asparaginase in AYA ALL, suggesting that therapy protocol is critical in the treatment performance of this group.