Premium
Survival and specific outcome of sickle cell disease patients after renal transplantation
Author(s) -
Gérardin Christel,
Moktefi Anissa,
Couchoud Cécile,
Duquesne Alyette,
Ouali Nacera,
Gataut Philippe,
Karras Alexandre,
Anglicheau Dany,
Lefaucheur Carmen,
Figueres Lucile,
Albano Laetitia,
Lionet Arnaud,
Novion Marine,
Ziliotis MarieJulia,
Louis Magali,
Del Bello Arnaud,
Matig Marie,
Dahan Karine,
Habibi Anoosha,
Galacteros Frederic,
Bartolucci Pablo,
Grimbert Philippe,
Audard Vincent
Publication year - 2019
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.16113
Subject(s) - medicine , transplantation , dialysis , disease , cytomegalovirus , kidney transplantation , end stage renal disease , surgery , viral disease , immunology , herpesviridae , virus
Summary The prognosis of sickle cell disease (SCD) patients who need dialysis is poor, but experience with kidney transplantation is limited. This study assessed the characteristics of 36 SCD patients undergoing renal transplantation. Immediate post‐surgical complications occurred in 25% of cases. Cytomegalovirus and bacterial infections were frequently observed. Twelve patients died after a median follow‐up period of 17·4 months. Overall patient survival was significantly lower in SCD than in the control group without significant difference for overall death‐censored graft survival. Our data suggest that renal transplantation should be systematically considered in SCD patients with end‐stage renal disease.