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Expression of GNAZ , encoding the Gα z protein, predicts survival in mantle cell lymphoma
Author(s) -
Mundt Filip,
Merrien Magali,
Nygren Lina,
Sutton Lesley A.,
Christensson Birger,
Wahlin Björn E.,
Rosenquist Richard,
Sander Birgitta,
Wasik Agata M.
Publication year - 2019
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15810
Subject(s) - mantle cell lymphoma , lymphocytosis , lymphoma , malignancy , cancer research , biology , pathology , medicine , microbiology and biotechnology , immunology
Summary Mantle cell lymphoma ( MCL ), a malignancy of B‐lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real‐time quantitative polymerase chain reaction data from 18 sorted primary MCL cells and 108 MCL biopsies compared to non‐malignant tissue, reveals that GNAZ expression predicts poor clinical outcome of MCL patients (Cox regression, P = 0·014) and lymphocytosis (Mann‐Whitney, P = 0·011). We show that GNAZ translates to Gα z protein – a signalling molecule within the G‐protein coupled receptor network. Our findings suggest that GNAZ / Gα z contribute to the MCL pathobiology.