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Clinical and biological features of paediatric acute myeloid leukaemia ( AML ) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML ‐05 study
Author(s) -
Miyamura Takako,
Moritake Hiroshi,
Nakayama Hideki,
Tanaka Shiro,
Tomizawa Daisuke,
Shiba Norio,
Saito Akiko M.,
Tawa Akio,
Shimada Akira,
Iwamoto Shotaro,
Hayashi Yasuhide,
Koike Takashi,
Horibe Keizo,
Manabe Atsushi,
Mizutani Shuki,
Taga Takashi,
Adachi Souichi
Publication year - 2019
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15799
Subject(s) - medicine , myeloid leukaemia , lymphoma , oncology , overall survival , myeloid
Summary The prognosis of paediatric acute myeloid leukaemia ( AML ) with primary induction failure ( PIF ) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML ‐05 study. The 3‐year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3 ‐internal tandem duplication, NUP98‐NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF . More effective treatment strategies based on leukaemia biology need to be urgently explored.