Premium
Contribution of immunoglobulin lambda light chain gene rearrangement analysis in the diagnosis of B‐cell neoplasms
Author(s) -
Paterson Anna L.,
ElDaly Hesham,
RasoBarnett Livia,
Du MingQing,
Giger Olivier,
Soilleux Elizabeth,
Roberts Thomas,
Huang Yuanxue,
Bibawi Hani,
Matharu Baljinder,
Bench Anthony,
Scott Mike A.,
Liu Hongxiang
Publication year - 2019
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15762
Subject(s) - gene rearrangement , immunoglobulin light chain , antibody , biology , immunoglobulin heavy chain , b cell , gene , microbiology and biotechnology , immunoglobulin gene , genetics
Summary Identification of clonal IGH , IGK and IGL gene rearrangements offers diagnostic adjunct in suspected B‐cell neoplasms. However, many centres omit IGL analysis as its value is uncertain. A review of 567 cases with IGH , IGK and IGL rearrangement assessed using BIOMED‐2 assays showed clonal immunoglobulin gene rearrangement in 54% of cases, of which 24% had a clonal IGL rearrangement. In two cases, the clonal rearrangement was detected exclusively by IGL analysis. This finding demonstrates the added value of IGL analysis for clonality assessment, especially in suspected B‐cell neoplasms in which a clonal IGH and/or IGK rearrangement is not detected or is equivocal.