Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia | Zendy

BarzilaiBirenboim Shlomit | Zendy; AradCohen Nira | Zendy; Nirel Ronit | Zendy; Avrahami Galia | Zendy; Harlev Dan | Zendy; Gilad Gil | Zendy; Elhasid Ronit | Zendy; Izraeli Shai | Zendy; Litichever Naomi | Zendy; Elitzur Sarah | Zendy

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Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia

Author(s) -

BarzilaiBirenboim Shlomit,

AradCohen Nira,

Nirel Ronit,

Avrahami Galia,

Harlev Dan,

Gilad Gil,

Elhasid Ronit,

Izraeli Shai,

Litichever Naomi,

Elitzur Sarah

Publication year - 2019

Publication title -

british journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.907

H-Index - 186

eISSN - 1365-2141

pISSN - 0007-1048

DOI - 10.1111/bjh.15752

Subject(s) - medicine , thrombophilia , venous thromboembolism , factor v leiden , pediatrics , anticoagulant , thrombosis , venous thrombosis

Summary This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism ( VTE ) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia ( ALL ) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. 2·9%, P < 0·01). Patients with thrombophilia had higher VTE rates VTE (26·5% vs. 5·6%, P < 0·001). None of the thrombophilic children given prophylaxis had severe VTE . Routine evaluation for inherited thrombophilia followed by thromboprophylaxis when findings are positive may benefit at‐risk patients with ALL .

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