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Cancer specific survival in patients with sickle cell disease
Author(s) -
Brunson Ann,
Keegan Theresa H. M.,
Mahajan Anjlee,
Paulukonis Susan,
Wun Ted
Publication year - 2019
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15687
Subject(s) - medicine , cancer , proportional hazards model , disease , hazard ratio , oncology , cancer registry , incidence (geometry) , survival analysis , confidence interval , physics , optics
Summary Sickle cell disease ( SCD ) patients have a higher incidence of certain cancers, but no studies have determined the impact of cancer on survival among SCD patients. SCD patients ( n = 6423), identified from state‐wide hospitalisation data, were linked to the California Cancer Registry (1988–2014). Multivariable Cox proportional hazards regression was used to examine survival. Among SCD patients, a cancer diagnosis was associated with a 3‐fold increased hazard of death. Compared to matched cancer patients without SCD , SCD was associated with worse overall survival, but not cancer‐specific survival, suggesting that SCD cancer patients should be treated with similar therapeutic intent.