Premium
Hepatitis E virus infection after haploidentical haematopoietic stem cell transplantation: incidence and clinical course
Author(s) -
Tang FeiFei,
Mo XiaoDong,
Wang Yu,
Yan ChenHua,
Chen YuHong,
Chen Huan,
Han Wei,
Chang YingJun,
Zhang HaiYing,
Xie YanDi,
Ma Hui,
Wei Lai,
Xu LanPing,
Huang XiaoJun,
Zhang XiaoHui
Publication year - 2019
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15672
Subject(s) - hepatitis e virus , medicine , hepatitis e , serology , hematopoietic stem cell transplantation , incidence (geometry) , immunology , transplantation , virology , antibody , biology , genotype , biochemistry , physics , gene , optics
Summary Hepatitis E virus ( HEV ) is increasingly found to cause hepatitis in allogeneic haematopoietic stem cell transplantation ( HSCT ) patients. However, little is known about HEV infection in patients receiving haploidentical HSCT (haplo‐ HSCT ). Here, we retrospectively evaluate the incidence and clinical course of HEV infection in haplo‐ HSCT patients. From January 2014 to July 2017, 177 patients with unexplained elevated transaminases after receiving haplo‐ HSCT at Peking University Institute of Haematology were screened for HEV using HEV serology. HEV RNA was assessed in blood samples when HEV ‐IgG and/or IgM antibodies were positive. Acute HEV infection was identified in 7 patients (3·9%), 1 of whom had developed a chronic HEV infection. The median time from haplo‐ HSCT to HEV infection was 17·5 (range, 6–55) months. HEV infection was confirmed by the presentation of anti‐ HEV IgM + anti‐ HEV IgG (rising) ( n = 5) or HEV ‐ RNA + anti‐ HEV IgM + anti‐ HEV IgG ( n = 2). None of the patients died of HEV infection directly: 2 patients with HEV infection died showing signs of ongoing hepatitis, and 5 patients cleared HEV with a median duration of HEV infection of 1·5 (range, 1·0–5·7) months. In conclusion, HEV infection is a rare but serious complication after haplo‐ HSCT . We recommend screening of HEV in haplo‐ HSCT .