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Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high‐risk or relapsed ALL – results of the ALL ‐ SCT 2003 trial
Author(s) -
Kuhlen Michaela,
Bader Peter,
Sauer Martin,
Albert Michael H.,
Gruhn Bernd,
Güngör Tayfun,
Kropshofer Gabriele,
Lang Peter,
Lawitschka Anita,
Metzler Markus,
Pentek Falk,
Rossig Claudia,
Schlegel Paul G.,
Schrappe Martin,
Schrum Johanna,
Schulz Ansgar,
Schwinger Wolfgang,
Stackelberg Arend,
Strahm Brigitte,
Suttorp Meinolf,
Luettichau Irene Teichertvon,
Wößmann Wilhelm,
Borkhardt Arndt,
Meisel Roland,
Poetschger Ulrike,
Glogova Evgenia,
Peters Christina
Publication year - 2018
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15511
Subject(s) - medicine , cumulative incidence , hazard ratio , hematopoietic stem cell transplantation , transplantation , incidence (geometry) , graft versus host disease , gastroenterology , pediatrics , confidence interval , immunology , physics , optics
Summary Osteonecrosis ( ON ) was prospectively assessed in 557 children and adolescents in the Berlin‐Frankfurt‐Münster Stem Cell Transplantation in children with acute lymphoblastic leukaemia 2003 trial. Median age at haematopoietic stem cell transplantation ( HSCT ) was 10·3 years (range 0·5–26). Cumulative incidence of symptomatic ON ( sON ) was 9% at 5 years (standard deviation 1%), median time from HSCT to diagnosis of sON was 12·4 months (range 1–126). Multivariate analysis identified age at HSCT [10–15 years vs. <10 years: hazard ratio ( HR ) 3·73, P = 0·009; >15 years vs. <10 years: HR 5·46, P = 0·001], diagnosis of sON prior to HSCT and chronic graft‐versus‐host disease (yes versus no: HR 2·696, P = 0·015) as significant independent risk factors for the development of sON .