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Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin–Frankfürt–Münster (I‐ BFM ) study group
Author(s) -
Klein Kim,
Hasle Henrik,
Abrahamsson Jonas,
De Moerloose Barbara,
Kaspers Gertjan J. L.
Publication year - 2018
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15499
Subject(s) - medicine , antibiotic prophylaxis , pediatrics , family medicine , antibiotics , microbiology and biotechnology , biology
Summary Prevention of infections is of obvious relevance in paediatric patients with acute myeloid leukaemia ( AML ). However, recommendations are often non‐specific and supported by low‐quality evidence, resulting in divergent infection preventive regimens. Using a web‐based survey, we investigated the infection prophylaxis guidelines of 22 paediatric AML study groups affiliated to the international Berlin–Frankfürt–Münster study group. In order to evaluate differences in daily practice among hospitals, representatives ( n = 27) from the Nordic Society for Paediatric Haematology and Oncology‐Dutch‐Belgium‐Hong Kong ‐ AML study group participated in a slightly modified survey. Seven study groups (32%) advise gram‐negative antibiotic prophylaxis, mainly with fluoroquinolones ( n = 6). Gram‐positive prophylaxis is prescribed by eight groups (36%). Over 60% of the study groups prescribe food and social restrictions, but the specific topics and strictness differ widely. According to the hospital‐based survey, sites roughly comply with common study group guidelines. However, the use of any gram‐negative antibiotic prophylaxis, the specific prophylactic antifungal agent and the strictness of the food and social restrictions differ substantially between the hospitals. Despite a long history of close collaboration, many differences are still present between the affiliated groups. The results of this survey provide an appropriate baseline measure to study the emergence and impact of future guidelines on infection prophylaxis in paediatric AML .