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Impairment of bone marrow endothelial progenitor cells in acute graft‐versus‐host disease patients after allotransplant
Author(s) -
Cao XieNa,
Kong Yuan,
Song Yang,
Shi MinMin,
Zhao HongYan,
Wen Qi,
Lyu ZhongShi,
Duan CaiWen,
Wang Yu,
Xu LanPing,
Zhang XiaoHui,
Huang XiaoJun
Publication year - 2018
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15456
Subject(s) - cytopenia , medicine , haematopoiesis , bone marrow , progenitor cell , immunology , cd34 , angiogenesis , pathogenesis , graft versus host disease , stem cell , transplantation , cancer research , biology , genetics
Summary Graft‐versus‐host disease ( GVHD ) is a major complication after allogeneic haematopoietic stem cell transplantation (allo‐ HSCT ) that is frequently associated with bone marrow ( BM ) suppression, and clinical management is challenging. BM endothelial progenitor cells ( EPC s) play crucial roles in the regulation of haematopoiesis and thrombopoiesis. However, little is known regarding the functional roles of BM EPC s in acute GVHD ( aGVHD ) patients. In the current prospective case‐control study, reduced and dysfunctional BM EPC s, characterized by decreased migration and angiogenesis capacities and increased levels of reactive oxygen species ( ROS ) and apoptosis, were found in aGVHD patients compared with those without aGVHD . Moreover, lower frequency and increased levels of ROS , apoptosis and DNA damage, but reduced colony‐forming unit‐plating efficiency were found in BM CD 34 + cells of aGVHD patients compared with those without aGVHD . The severity of aGVHD and GVHD ‐mediated cytopenia was associated with BM EPC impairment in aGVHD patients. In addition, the EPC impairment positively correlated with ROS level. Taken together, our results suggest that reduced and dysfunctional BM EPC s may be involved in the pathogenesis of aGVHD . Although these findings require validation, our data indicate that improvement of BM EPC s may represent a promising therapeutic approach for aGVHD patients.