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Human Pegivirus infection and lymphoma risk and prognosis: a North American study
Author(s) -
Fama Angelo,
Xiang Jinhua,
Link Brian K.,
Allmer Cristine,
Klinzman Donna,
Feldman Andrew L.,
Nowakowski Grzegorz S.,
Liebow Mark,
Larson Melissa C.,
Maurer Matthew J.,
Ansell Stephen M.,
Novak Anne J.,
Asmann Yan W.,
Slager Susan L.,
Call Timothy G.,
Habermann Thomas M.,
Cerhan James R.,
Stapleton Jack T.
Publication year - 2018
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15416
Subject(s) - lymphoma , gb virus c , medicine , hazard ratio , odds ratio , immunology , confidence interval , gastroenterology , virus , viral disease , flaviviridae
Summary We evaluated the association of Human Pegivirus ( HP gV) viraemia with risk of developing lymphoma, overall and by major subtypes. Because this virus has also been associated with better prognosis in the setting of co‐infection with human immunodeficiency virus, we further assessed the association of HP gV with prognosis. We used risk factor data and banked plasma samples from 2094 lymphoma cases newly diagnosed between 2002 and 2009 and 1572 frequency‐matched controls. Plasma samples were tested for HP gV RNA by reverse transcription polymerase chain reaction ( RT ‐ PCR ), and those with RNA concentrations <5000 genome equivalents/ml were confirmed using nested RT ‐ PCR methods. To assess the role of HP gV in lymphoma prognosis, we used 2948 cases from a cohort study of newly diagnosed lymphoma patients (included all cases from the case‐control study). There was a positive association of HP gV viraemia with risk of lymphoma overall (Odds ratio = 2·14; 95% confidence interval [ CI ] 1·63–2·80; P < 0·0001), and for all major subtypes except Hodgkin lymphoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma, and this was not confounded by other lymphoma risk factors. In contrast, there was no association of HP gV viraemia with event‐free survival (Hazard ratio [ HR ] = 1·00; 95% CI 0·85–1·18) or overall survival ( HR = 0·97; 95% CI 0·79–1·20) for lymphoma overall, or any of the subtypes. These data support the hypothesis for a role of HP gV in the aetiology of multiple lymphoma subtypes.