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In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics
Author(s) -
Rigolin Gian Matteo,
Saccenti Elena,
Guardalben Emanuele,
Cavallari Maurizio,
Formigaro Luca,
Zagatti Barbara,
Visentin Andrea,
Mauro Francesca R.,
Lista Enrico,
Bassi Cristian,
Lupini Laura,
Quaglia Francesca Maria,
Urso Antonio,
Bardi Maria Antonella,
Bonaldi Laura,
Volta Eleonora,
Tammiso Elisa,
Ilari Caterina,
Cafforio Luciana,
Melandri Aurora,
Cavazzini Francesco,
Negrini Massimo,
Semenzato Gianpietro,
Trentin Livio,
Foà Robin,
Cuneo Antonio
Publication year - 2018
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15174
Subject(s) - karyotype , clone (java method) , chronic lymphocytic leukemia , cytogenetics , medicine , multivariate analysis , oncology , chromosome , immunology , biology , pathology , leukemia , genetics , gene
Summary Complex karyotype ( CK ) is a negative prognostic factor in chronic lymphocytic leukaemia ( CLL ). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival ( P = 0·025) and a shorter time to first treatment ( P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high‐risk CLL patients with distinct clinical and biological characteristics.