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Haemostasis and innate immunity – a complementary relationship
Author(s) -
Keragala Charithani B.,
Draxler Dominik F.,
McQuilten Zoe K.,
Medcalf Robert L.
Publication year - 2018
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15062
Subject(s) - innate immune system , immunology , complement system , sepsis , disease , immunity , medicine , coagulation , alternative complement pathway , classical complement pathway , biology , immune system , pathology
Summary Coagulation and innate immunity are linked evolutionary processes that orchestrate the host defence against invading pathogens and injury. The complement system is integral to innate immunity and shares numerous interactions with components of the haemostatic pathway, helping to maintain physiological equilibrium. The term ‘immunothrombosis’ was introduced in 2013 to embrace this process, and has become an area of much recent interest. What is less apparent in the literature however is an appreciation of the clinical manifestations of the coagulation‐complement interaction and the consequences of dysregulation of either system, as seen in many inflammatory and thrombotic disease states, such as sepsis, trauma, atherosclerosis, antiphospholipid syndrome ( APS ), paroxysmal nocturnal haemoglobinuria ( PNH ) and some thrombotic microangiopathies to name a few. The growing appreciation of this immunothrombotic phenomenon will foster the drive for novel therapies in these disease states, including anticoagulants as immunomodulators and targeted molecular therapies.