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Haematology patients and the risk of transfusion transmitted infection
Author(s) -
Ainley Louise I.,
Hewitt Patricia E
Publication year - 2018
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15030
Subject(s) - medicine , hematology , population , clotting factor , hepatitis c virus , hepatitis virus , blood transfusion , transmission (telecommunications) , immunology , virus , hepatitis , pediatrics , environmental health , electrical engineering , engineering
Summary A 2014 study by NHS Blood and Transplant indicated that over one quarter of red cells were transfused to patients with haematological conditions. For platelet components, the figure is higher. Certain diagnostic groups, such as haemoglobinopathies, myelodysplastic syndromes and some haemato‐oncology patients, receive multiple transfusion episodes, either over long periods, or more intensively over shorter periods. Haematology patients account for the majority of the multi‐transfused population. The risk of transfusion‐transmitted infection ( TTI ) increases with number of donor exposures, and the consequences of TTI are often more significant in immunosuppressed individuals. Historically, use of pooled plasma products in patients with clotting disorders resulted in widespread transmission of hepatitis B virus, hepatitis C virus and human immunodeficiency virus before effective screening and viral inactivation methods were introduced.