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Cell‐of‐origin classification by gene expression and MYC ‐rearrangements in diffuse large B‐cell lymphoma of children and adolescents
Author(s) -
Szczepanowski Monika,
Lange Jonas,
Kohler Christian W.,
MasqueSoler Neus,
Zimmermann Martin,
Aukema Sietse M.,
Altenbuchinger Michael,
Rehberg Thorsten,
Mahn Friederike,
Siebert Reiner,
Spang Rainer,
Burkhardt Birgit,
Klapper Wolfram
Publication year - 2017
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.14812
Subject(s) - chromosomal translocation , lymphoma , diffuse large b cell lymphoma , fluorescence in situ hybridization , cancer research , gene expression profiling , gene , biology , oncology , comparative genomic hybridization , in situ hybridization , gene expression , medicine , pathology , genetics , genome , chromosome
Summary We present the largest series of diffuse large B‐cell lymphoma (DLBCL) in patients younger than 18 years analysed to date by gene expression profiling using Nanostring technology to identify molecular subtypes and fluorescent in situ hybridization for translocations of MYC . We show that the activated B cell‐like subtype of DLBCL is exceedingly rare in children and – in contrast to adults‐ not associated with outcome. Furthermore, we review the current literature and demonstrate that MYC translocations are not more frequent in paediatric compared to adult DLBCL. A prognostic role of MYC in the paediatric age groups seems unlikely.