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Physical activity, obesity and survival in diffuse large B‐cell and follicular lymphoma cases
Author(s) -
Boyle Terry,
Connors Joseph M.,
Gascoyne Randy D.,
Berry Brian R.,
Sehn Laurie H.,
Bashash Morteza,
Spinelli John J.
Publication year - 2017
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.14702
Subject(s) - follicular lymphoma , medicine , lymphoma , hazard ratio , diffuse large b cell lymphoma , body mass index , confidence interval , international prognostic index , non hodgkin's lymphoma , oncology , obesity , proportional hazards model , gastroenterology
Summary There is limited information concerning the impact of physical activity and obesity on non‐Hodgkin lymphoma ( NHL ) prognosis. We examined the associations between pre‐diagnosis physical activity and body mass index ( BMI ) with survival in 238 diffuse large B‐cell ( DLBCL ) and 175 follicular lymphoma cases, with follow‐up from 2000 to 2015. The most physically active DLBCL cases had 41% lower risk of dying in the follow‐up period than the least active [Hazard ratio ( HR ) = 0·59, 95% confidence interval ( CI ) = 0·36–0·96], while obese follicular lymphoma cases had a 2·5‐fold risk of dying ( HR = 2·52, 95% CI = 1·27–5·00) compared with cases with normal BMI . NHL ‐specific survival results were similar.