Premium
Antibiotic use as a marker of acute infection and risk of first and recurrent venous thrombosis
Author(s) -
Timp Jasmijn F.,
Cannegieter Suzanne C.,
Tichelaar Vladimir,
Braekkan Sigrid K.,
Rosendaal Frits R.,
Cessie Saskia,
Lijfering Willem M.
Publication year - 2017
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.14551
Subject(s) - medicine , antibiotics , hazard ratio , risk factor , proportional hazards model , confidence interval , venous thrombosis , thrombosis , surgery , microbiology and biotechnology , biology
Summary A role for transient infections in the aetiology of venous thrombosis ( VT ) has been suggested. This study aimed to determine whether individuals who receive antibiotic treatment (as a proxy for infections) have an increased risk of first and recurrent VT and whether infections should be seen as a provoking risk factor for VT . We used the self‐controlled case series method to study the risk of first VT during antibiotic prescriptions. The risk of recurrent VT during antibiotic use was estimated by of time‐dependent Cox‐regression. A total of 2547 patients with a first VT were included and followed for a median of 5·9 years for recurrence (1999–2010), in whom 114 first events occurred during antibiotic use. We found a five‐fold increased risk of first VT during antibiotic treatment: [incidence‐rate‐ratio 5·0; 95% confidence interval ( CI ), 4·0–6·1]. Antibiotic use was associated with a 2·0‐fold (95% CI , 1·1–4·0) increased risk of recurrent VT . Patients with an unprovoked first VT who used antibiotics shortly before this event, had a similar risk of recurrence as patients with a provoked first VT (adjusted hazard ratio 1·1; 95% CI , 0·7–1·7). Individuals who receive antibiotics have an increased risk of first and recurrent VT and infections should be considered a provoking risk factor for VT .