Premium
Investigation and management of IgM and Waldenström‐associated peripheral neuropathies: recommendations from the IWWM ‐8 consensus panel
Author(s) -
D'Sa Shirley,
Kersten Marie José,
Castillo Jorge J.,
Dimopoulos Meletios,
Kastritis Efstathios,
Laane Edward,
Leblond Véronique,
Merlini Giampaolo,
Treon Steven P.,
Vos Josephine M.,
Lunn Michael P.
Publication year - 2017
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.14492
Subject(s) - medicine , waldenstrom macroglobulinemia , psychological intervention , consensus conference , monoclonal gammopathy , intensive care medicine , monoclonal , pathology , immunology , monoclonal antibody , antibody , psychiatry , lymphoma
Summary Paraproteinaemic neuropathies are a heterogeneous group of disorders most frequently associated with IgM monoclonal gammopathies including Waldenström macroglobulinaemia ( WM ). Their consequences are significant for affected patients, and their management challenging for their physicians. The variability in clinical presentation and time course hamper classification and management. The indications for invasive investigations such as cerebrospinal fluid analysis, nerve conduction tests and sensory nerve biopsies are unclear, and the optimum way to measure clinical response to treatment unknown. When to intervene and and how to treat, also present challenges to physicians. As part of its latest deliberations at the International Workshops on WM ( IWWM ) in London, UK (August 2014), the IWWM 8 panel have proposed a consensus approach to the diagnosis and management of peripheral neuropathies associated with IgM monoclonal gammopathies, including WM . Importantly, a consensus regarding the use of clinical outcome measures and recommended models of care for this group of patients is discussed, as well as appropriate treatment interventions.