Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia | Zendy

Brown Fiona C. | Zendy; Cifani Paolo | Zendy; Drill Esther | Zendy; He Jie | Zendy; Still Eric | Zendy; Zhong Shan | Zendy; Balasubramanian Sohail | Zendy; Pavlick Dean | Zendy; Yilmazel Bahar | Zendy; Knapp Kristina M. | Zendy; Alonzo Todd A. | Zendy; Meshinchi Soheil | Zendy; Stone Richard M. | Zendy; Kornblau Steven M. | Zendy; Marcucci Guido | Zendy; Gamis Alan S. | Zendy; Byrd John C. | Zendy; Gonen Mithat | Zendy; Levine Ross L. | Zendy; Kentsis Alex | Zendy

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Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia

Author(s) -

Brown Fiona C.,

Cifani Paolo,

Drill Esther,

He Jie,

Still Eric,

Zhong Shan,

Balasubramanian Sohail,

Pavlick Dean,

Yilmazel Bahar,

Knapp Kristina M.,

Alonzo Todd A.,

Meshinchi Soheil,

Stone Richard M.,

Kornblau Steven M.,

Marcucci Guido,

Gamis Alan S.,

Byrd John C.,

Gonen Mithat,

Levine Ross L.,

Kentsis Alex

Publication year - 2017

Publication title -

british journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.907

H-Index - 186

eISSN - 1365-2141

pISSN - 0007-1048

DOI - 10.1111/bjh.14413

Subject(s) - myeloid leukaemia , myeloid leukemia , medicine , myeloid , gene , chemotherapy , induction chemotherapy , cancer research , mutation , oncology , immunology , biology , bioinformatics , genetics

Summary Cure rates of children and adults with acute myeloid leukaemia ( AML ) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in haematological malignancies. SETBP 1 , ASXL 1 and RELN mutations were significantly associated with primary chemoresistance. We identified genomic alterations not previously described in AML , together with distinct genes that were significantly overexpressed in therapy‐resistant AML . Defined gene mutations were sufficient to explain primary induction failure in only a minority of cases. Thus, additional genetic or molecular mechanisms must cause primary chemoresistance in paediatric and adult AML .

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