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Advances in understanding the pathogenesis of CNS acute lymphoblastic leukaemia and potential for therapy
Author(s) -
FrishmanLevy Liron,
Izraeli Shai
Publication year - 2017
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.14411
Subject(s) - pathogenesis , medicine , disease , central nervous system , immunology , bioinformatics , pathology , biology
Summary Central nervous system acute lymphoblastic leukaemia ( CNS ‐ ALL ) is a major clinical problem. CNS ‐directed ‘prophylactic’ chemo‐ or radio – therapy is associated with significant early and long‐term toxicity. Moreover, greater than a third of the relapses occur in the CNS . To design specific, more effective and less toxic therapy and for personalized precise adjustment of prophylactic therapy there is a need for better understanding of the biology of this disease. Specifically, the precise neurotropic mechanisms of ALL are currently unclear, as is the pathogenesis of CNS relapse. Here we review and contrast the recent findings with earlier studies of pathogenesis of CNS leukaemia. We also describe the challenges in research of this devastating complication of ALL .

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