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Re‐evaluation of progenitor thresholds and expectations for haematopoietic recovery based on an analysis of 810 autologous transplants: Implications for quality assurance
Author(s) -
Watts Michael J.,
Ings Stuart J.,
Balsa Carmen,
Antonio Andrew,
Hack Simon,
Linch David C.
Publication year - 2016
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.14276
Subject(s) - progenitor cell , haematopoiesis , cd34 , quality assurance , medicine , granulocyte , stem cell , biology , pathology , microbiology and biotechnology , external quality assessment
Haematological engraftment was assessed in 804 autologous transplants. Neutrophil recovery occurred in over 99% within 14 d but platelet recovery was delayed beyond this time in 14·8%. Time to recovery was dependent on the progenitor cell dose infused. The minimum CD 34 + cell threshold adopted in this study (2 × 10 6 /kg) was safe although recovery was faster with a dose >5 × 10 6 /kg. CD34 + cell doses of between 1 and 2 × 10 6 /kg were also acceptable if either the granulocyte‐macrophage colony‐forming cell dose exceeded 2 × 10 5 /kg or this dose was due to splitting a higher yield harvest. Prompt neutrophil recovery affords important quality assurance for laboratory processing.