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Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium
Author(s) -
Schinasi Leah H.,
Brown Elizabeth E.,
Camp Nicola J.,
Wang Sophia S.,
Hofmann Jonathan N.,
Chiu Brian C.,
Miligi Lucia,
Beane Freeman Laura E.,
Sanjose Silvia,
Bernstein Leslie,
Monnereau Alain,
Clavel Jacqueline,
Tricot Guido J.,
Atanackovic Djordje,
Cocco Pierluigi,
Orsi Laurent,
Dosman James A.,
McLaughlin John R.,
Purdue Mark P.,
Cozen Wendy,
Spinelli John J.,
Roos Anneclaire J.
Publication year - 2016
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.14199
Subject(s) - medicine , odds ratio , family history , multiple myeloma , relative risk , confidence interval , etiology , first degree relatives , oncology , cancer , demography , family aggregation , disease , sociology
Summary Family clusters of multiple myeloma ( MM ) suggest disease heritability. Nevertheless, patterns of inheritance and the importance of genetic versus environmental risk factors in MM aetiology remain unclear. We pooled data from eleven case‐control studies from the International Multiple Myeloma Consortium to characterize the association of MM risk with having a first‐degree relative with a history of a lympho‐haematapoietic cancer. Unconditional logistic regression models, adjusted for study, sex, age and education level, were used to estimate associations between MM risk and having a first‐degree relative with a history of non‐Hodgkin lymphoma, Hodgkin lymphoma, leukaemia or MM . Sex, African American race/ethnicity and age were explored as effect modifiers. A total of 2843 cases and 11 470 controls were included. MM risk was elevated in association with having a first‐degree relative with any lympho‐haematapoietic cancer (Odds Ratio (OR) = 1·29, 95% Confidence Interval (CI): 1·08–1·55). The association was particularly strong for having a first‐degree relative with MM (OR = 1·90, 95% CI: 1·26–2·87), especially among men (OR = 4·13, 95% CI: 2·17–7·85) and African Americans (OR = 5·52, 95% CI: 1·87–16·27).These results support the hypothesis that genetic inheritance plays a role in MM aetiology. Future studies are warranted to characterize interactions of genetic markers with environmental exposures.