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Adolescent and young adult non‐Hodgkin lymphoma
Author(s) -
Hochberg Jessica,
ElMallawany Nader Kim,
Abla Oussama
Publication year - 2016
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.14074
Subject(s) - lymphoma , medicine , hodgkin lymphoma , young adult , lymphoblastic lymphoma , incidence (geometry) , population , anaplastic large cell lymphoma , oncology , pediatrics , immunology , t cell , environmental health , physics , immune system , optics
Summary Non‐Hodgkin lymphoma ( NHL ) is a heterogeneous group of lymphoid malignancies accounting for a significant portion of cancers occurring in children, adolescents and young adults with an increasing incidence with age. The adolescent and young adult ( AYA ) population presents a specific set of characteristics and challenges. The most common diseases occurring in adolescents and young adults include Burkitt lymphoma, lymphoblastic lymphoma, diffuse large B‐cell lymphoma, anaplastic large cell lymphoma and primary mediastinal B‐cell lymphoma. There is also a higher incidence of primary central nervous system lymphoma in AYA patients. Cure rates largely depend on risk‐stratification, and are generally superior to outcomes in comparison to older adult data but less than in younger children. Here, we review the unique clinical and biological characteristics of NHL occurring in the AYA population with a focus on how to achieve similar curative outcomes in AYA that have been established in younger cohorts.