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Can chronic myeloid leukaemia in children and adolescents be successfully treated without haematopoietic stem cell transplant? A single centre experience
Author(s) -
Giona Fiorina,
Moleti Maria L.,
De Benedittis Daniela,
Santopietro Michelina,
Nanni Mauro,
Testi Anna M.,
Orlando Sonia,
Iori Anna P.,
Piciocchi Alfonso,
Gottardi Enrico,
Barberi Walter,
Diverio Daniela,
Saglio Giuseppe,
Foà Robin
Publication year - 2016
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13991
Subject(s) - medicine , chronic myeloid leukaemia , haematopoiesis , stem cell , overall survival , transplantation , myeloid , oncology , hematopoietic stem cell transplantation , gastroenterology , genetics , biology
Summary We analysed the long‐term outcome of 35 children and adolescents (<20 years at diagnosis) with chronic myeloid leukaemia ( CML ) in chronic phase: 20 patients had received interferon‐alpha and/or tyrosine kinase inhibitors ( TKI s), and 15 underwent a haematopoietic stem cell transplant. The 10‐year survival probabilities were similar in transplanted and non‐transplanted patients (73·3% vs. 72·1%, respectively), whereas the survival probability was significantly lower in patients diagnosed before 1999 compared to those diagnosed afterwards (62·1% vs. 100%, P = 0·0384). The availability of TKI s and the standardized molecular monitoring have significantly improved treatment, management and outcome in children and adolescents with CML .