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Effects of Poloxamer 188 on red blood cell membrane properties in sickle cell anaemia
Author(s) -
Sandor Barbara,
Marin Mickaël,
Lapoumeroulie Claudine,
Rabaï Miklos,
Lefevre Sophie D.,
Lemonne Nathalie,
El Nemer Wassim,
Mozar Anaïs,
Français Olivier,
Le Pioufle Bruno,
Connes Philippe,
Le Van Kim Caroline
Publication year - 2016
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13937
Subject(s) - poloxamer , red blood cell , blood viscosity , medicine , cell adhesion , clinical trial , sickle cell anemia , adhesion , cell , chemistry , biochemistry , disease , organic chemistry , copolymer , polymer
Summary Vaso‐occlusive crisis ( VOC ) is the main acute complication in sickle cell anaemia ( SS ) and several clinical trials are investigating different drugs to improve the clinical severity of SS patients. A phase III study is currently exploring the profit of Velopoloxamer in SS during VOC s. We analysed, in‐vitro , the effect of poloxamer (P188) on red blood cell ( RBC ) properties by investigating haemorheology, mechanical and adhesion functions using ektacytometry, microfluidics and dynamic adhesion approaches, respectively. We show that poloxamer significantly reduces blood viscosity, RBC aggregation and adhesion to endothelial cells, supporting the beneficial use of this molecule in SS therapy.