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Thrombopoietic status of patients on haemodialysis
Author(s) -
Bat Taha,
Bat Betul E.,
ElMoghraby Ahmed,
Patel Samir,
Feng Xingmin,
Dunbar Cynthia E.,
Sarac Erdal
Publication year - 2016
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13918
Subject(s) - thrombopoietin , thrombopoiesis , medicine , dialysis , platelet , hemodialysis , complication , romiplostim , bone marrow , surgery , urology , megakaryocyte , haematopoiesis , genetics , stem cell , biology
Summary Thrombocytopenia is a potential dialysis‐related treatment complication. Developments in bio‐compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number ( AIPN ) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre‐ and post‐ haemodialysis in a cohort of 45 well‐characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.