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The evolution of T‐cell depletion in haploidentical stem‐cell transplantation
Author(s) -
OrGeva Noga,
Reisner Yair
Publication year - 2016
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13868
Subject(s) - medicine , transplantation , stem cell , immune system , bone marrow , bone marrow transplantation , immunology , t cell , cell , sibling , graft versus host disease , cancer research , biology , microbiology and biotechnology , genetics , psychology , developmental psychology
Summary T‐cell depletion ( TCD ) can prevent the onset of graft‐versus‐host disease (Gv HD ) in animal models of bone marrow transplantation; this manipulation enabled the successful application in the 1980s of T‐cell depleted bone marrow ( BM ) for the treatment of babies with severe combined immune deficiency ( SCID ). However, in leukaemia patients, implementation of T‐cell depletion has been more difficult, especially due to high rate of graft‐rejection, leukaemia relapse and delayed immune reconstitution. These hurdles were gradually overcome by modifying the cell composition of the graft, and by reducing the toxicities associated with conditioning protocols. Although no ‘gold standard’ TCD method exists, T‐cell depletion in its modern forms could offer clinical benefit, even for patients with a matched sibling donor.