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Survival of childhood acute lymphoid leukaemia in Yorkshire by clinical trial era, 1990–2011
Author(s) -
Laar Marlous,
Kinsey Sally E.,
Feltbower Richard G.
Publication year - 2015
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13524
Subject(s) - hazard ratio , medicine , confidence interval , overall survival , clinical trial , population , environmental health
Summary Gender‐specific differences in survival by clinical trial era in Yorkshire were assessed for children with acute lymphoid leukaemia ( ALL ) enrolled onto UKALLXI , ALL 97/99 or UKALL 2003 ( n = 630; 1990–2011). For males, there was a non‐significant improvement in survival for ALL 97/99 [hazard ratio ( HR ) = 0·77; 95% confidence interval ( CI ) 0·43–1·42) and a significant improvement for UKALL 2003 ( HR = 0·50; 95% CI 0·25–0·99) compared to UKALLXI . For females, survival was significantly improved for ALL 97/99 ( HR = 0·33; 95% CI 0·14–0·78), and non‐significantly improved for UKALL 2003 ( HR = 0·51; 95% CI 0·25–1·08) compared to UKALLXI . Modest overall survival improvements masked clinically important gender‐specific changes over time by trial era, requiring confirmation in larger population‐based studies.