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Validation of the revised international prognostic scoring system ( IPSS ‐R) in patients with lower‐risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS ( EUMDS ) registry
Author(s) -
Swart Louise,
Smith Alex,
Johnston Thomas W.,
Haase Detlef,
Droste Jackie,
Fenaux Pierre,
Symeonidis Argiris,
Sanz Guillermo,
HellströmLindberg Eva,
Cermák Jaroslav,
Germing Ulrich,
Stauder Reinhard,
Georgescu Otilia,
MacKenzie Marius,
Malcovati Luca,
Holm Mette S.,
Almeida Antonio M.,
Mądry Krzysztof,
Slama Borhane,
GuerciBresler Agnes,
Sanhes Laurence,
BeyneRauzy Odile,
Luño Elisa,
Bowen David,
Witte Theo
Publication year - 2015
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13450
Subject(s) - international prognostic scoring system , myelodysplastic syndromes , medicine , univariate analysis , population , multivariate analysis , prospective cohort study , oncology , bone marrow , environmental health
Summary Baseline characteristics, disease‐management and outcome of 1000 lower‐risk myelodysplastic syndrome ( MDS ) patients within the European LeukaemiaNet MDS ( EUMDS ) Registry are described in conjunction with the validation of the revised International Prognostic Scoring System ( IPSS ‐R). The EUMDS registry confirmed established prognostic factors, such as age, gender and World Health Organization 2001 classification. Low quality of life ( EQ ‐5D visual analogue scale score) was significantly associated with reduced survival. A high co‐morbidity index predicted poor outcome in univariate analyses. The IPSS ‐R identified a large group of 247 patients with Low (43%) and Very low (23%) risk score within the IPSS intermediate‐1 patients. The IPSS ‐R also identified 32 High or Very high risk patients within the IPSS intermediate‐1 patients. IPSS ‐R was superior to the IPSS for predicting both disease progression and survival. Seventy percent of patients received MDS ‐specific treatment or supportive care, including red blood cell transfusions (51%), haematopoietic growth factors (58%) and iron chelation therapy (8%), within 2 years of diagnosis; while 30% of the patients only required active monitoring. The IPSS ‐R proved its utility as a more refined risk stratification tool for the identification of patients with a very good or poor prognosis and in this lower‐risk MDS population.