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Prognostic value of complete remission status at end‐of‐treatment FDG‐PET in R‐CHOP‐treated diffuse large B‐cell lymphoma: systematic review and meta‐analysis
Author(s) -
Adams Hugo J. A.,
Nievelstein Rutger A. J.,
Kwee Thomas C.
Publication year - 2015
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13420
Subject(s) - medicine , vincristine , rituximab , prednisone , diffuse large b cell lymphoma , chop , cyclophosphamide , meta analysis , lymphoma , oncology , progression free survival , nuclear medicine , gastroenterology , chemotherapy
Summary This study systematically reviewed and meta‐analysed the prognostic value of complete remission status at end‐of‐treatment 18 F‐fluoro‐2‐deoxy‐ d ‐glucose positron emission tomography ( FDG ‐ PET ) in diffuse large B‐cell lymphoma ( DLBCL ) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐ CHOP ). The systematic PubMed/ MEDLINE search yielded seven suitable studies comprising a total of 737 R‐ CHOP ‐treated DLBCL patients who were in complete remission at end‐of‐treatment FDG ‐ PET . Overall, the methodological quality of included studies was reasonable. The disease relapse rate among all patients with complete remission status according to end‐of‐treatment FDG ‐ PET ranged from 7·0% to 20·0%, with a weighted summary proportion of 13·7%. Five of seven studies reported progression‐free survival ( PFS ) of these patients at various specific time points, i.e., 2‐year PFS ( n = 1), estimated 3‐year PFS ( n = 3) and 5‐year PFS ( n = 1), which was 83%, 85–86·4% and 75%, respectively. Three of seven studies reported overall survival ( OS ) of these patients at various specific time points, i.e., estimated 3‐year OS ( n = 2) and estimated 5‐year OS ( n = 1), which were 90%, 93·6% and 83%, respectively. In conclusion, a non‐negligible proportion of R‐ CHOP ‐treated DLBCL patients who achieve complete remission according to end‐of‐treatment FDG ‐ PET experiences disease relapse during follow‐up.