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Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload
Author(s) -
Aygun Banu,
Mortier Nicole A.,
Kesler Karen,
Lockhart Alexandre,
Schultz William H.,
Cohen Alan R.,
Alvarez Ofelia,
Rogers Zora R.,
Kwiatkowski Janet L.,
Miller Scott T.,
Sylvestre Pamela,
Iyer Rathi,
Lane Peter A.,
Ware Russell E.
Publication year - 2015
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13280
Subject(s) - phlebotomy , medicine , hydroxycarbamide , ferritin , adverse effect , anemia , stroke (engine) , hemosiderosis , pediatrics , chemotherapy , mechanical engineering , engineering
Summary Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with only 33 adverse events, all of which were grade 2. Among 23 children completing 30 months of study treatment, the net iron balance was favourable (−8·7 mg Fe/kg) with significant decrease in ferritin, although liver iron concentration remained unchanged. Therapeutic phlebotomy was safe and well‐tolerated, with net iron removal in most children who completed 30 months of protocol‐directed treatment.