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Rituximab combined with Dexa BEAM followed by high dose therapy as salvage therapy in patients with relapsed or refractory B‐cell lymphoma: mature results of a phase II multicentre study
Author(s) -
Kirschey Sebastian,
Flohr Thomas,
Wolf Hans H.,
Frickhofen Norbert,
Gramatzki Martin,
Link Hartmut,
Basara Nadezda,
Peter Norma,
Meyer Ralf G.,
Schmitz Norbert,
Weidmann Eckhart,
Banat Andre,
Schulz Andrea,
Kolbe Karin,
Derigs Guenter,
Theobald Matthias,
Hess Georg
Publication year - 2015
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13234
Subject(s) - rituximab , refractory (planetary science) , salvage therapy , medicine , lymphoma , antibody therapy , oncology , chemotherapy , immunology , antibody , monoclonal antibody , biology , astrobiology
Summary Salvage therapy followed by high‐dose therapy ( HDT ) remains a mainstay for patients with relapsed lymphoma, however no optimal regimen has been defined. Here we report on the results of R‐Dexa BEAM (rituximab, dexamethasone, carmustine, etoposide, cytarabine, melphalan) followed by HDT . Patients aged 18–65 years, Eastern Cooperative Oncology Group performance score 0–2, with relapsed/refractory B‐cell non‐Hodgkin lymphoma ( NHL ) were eligible. R‐Dexa‐ BEAM was given for two cycles followed by stem cell mobilization and HDT . Primary endpoint of the trial was progression‐free‐survival ( PFS ). One hundred and three patients were included: aggressive NHL ( aNHL ): diffuse large B‐cell lymphoma 55, mantle cell lymphoma 7, follicular lymphoma (FL ) grade 3: 5, indolent Lymphoma ( iNHL ): FL grade 1–2: 29, marginal zone lymphoma 6, Immunocytoma 1. The overall response rate after salvage therapy was 62% for aNHL and 78% for iNHL patients. 66% of patients with aNHL and 86% with iNHL underwent HDT . Treatment‐related mortality for HDT was 1·3%. For aNHL patients, the median PFS was 0·83 years with 44% alive at the median follow‐up of 7·3 years. Corresponding figures for iNHL were: median PFS 3·7 years and 72% alive after 8 years. The combination of rituximab with Dexa BEAM followed by HDT resulted in high response rates and sustained remissions in responders. R‐Dexa BEAM followed by HDT can be considered a valid salvage option for NHL .